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KMID : 0370219960400030347
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Yakhak Hoeji
1996 Volume.40 No. 3 p.347 ~ p.350
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Post-Antibiotic Effect of LB20304, A New Quinolone Antibiotic
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안미정/Ahn MJ
백경숙/김무용/김인철/곽진환/Paek KS/Kim MY/Kim IC/Kwak JH
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Abstract
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The post-antibiotic effect (PAE), which is defined as the period of time lag that the target organisms resume normal growth rate after complete removal of the antibiotics, of LB20304 and ciprofloxacin was evaluated against Staphylococcus aureus 6538p and Escherichia coli 3190Y, respectively. The PAE was estimated by adding each antibiotic to a log phase of growth and incubating at 37oC for 1 h.Antibiotic was removed by centrifugation, and total viable cell counts were determined hourly for a further 10 h. The PAEs of LB20304 against S. aureus at concentrations of 1XMIC and 2mcg/ml were 10 min and 93min, respectively. LB20304 showed a comparable PAE to ciprofloxacin. Against E. coli, the PAE of LB20304 was also similar to that of ciprofloxacin at concentration of 4XMIC but it was much longer than that of ciprofloxacin at concentration of 2mcg/ml. LB20304 showed higher lethality than ciprofloxacin against both S. aureus and E. coli strains.
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